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Hard Leather allergic disease itself (autoimmune) disease and in tissue for unknown reasons. Which results from inflammation (Inflammation is often associated with autoimmune disease) led to the creation of collagen fibers (collagen) in various tissues increased more than usual. Cause tissue fibrosis (fibrosis) inserted in various organs computrition will be inserted in the skin, internal computrition organs and blood vessels. computrition
One. Stage called edematous phase skin will be red and swollen skin by hand (puffy hand) and limb swelling, stiffness may spread to the neck and face. Make wrinkles disappear and the skin on the face is grooved around the lips.
. 2 indurative phase called stiff skin swelling is reduced. But is there a darker skin stiffness and clearly. Some people are born with white skin, freckles, spots, freckles, black called salt and pepper skin fingers look pale green when in contact with cold (Raynaud's phenomenon), some people have skin finger holes called digital pitting scar if fingers pale green. may result in tissue death (gangrene) or a small incision (ischemic ulcer) at the fingertips, some skin tight, very rigid, making computrition strapping knuckle until the flexion deformities (flexion contracture), and Bone fingertips and fingers. shortened
Three. Term changes of the skin, called atrophic phase stage strap attached to the skin, muscles and bones. Can not pick up the skin. Some are very thin and break easily, dry the wound. The skin over the Bones such as the ankles, elbows, etc..
Dermatology is hard to disappear. And some of the skin is healed, especially those with slower disease progression computrition and no pathology of the internal organs. Stiffness, skin begins computrition to weaken and healed. White dots will fade, but some may see as hundreds of hard surface residual disease seen at the fingers and the face. However, for patients with the disease have a poor prognosis, often sooner. Are often associated with frequent pathology of internal organs. Especially pulmonary fibrosis (pulmonary fibrosis) computrition fibrosis in the myocardium (myocardial fibrosis) and the intestinal membrane. Patients died of a heart, lung, kidney, which usually occurs within 1-2 years after onset.
- Muscle pain Weakness of muscles Often occur in the muscles around the upper arm and thigh. Due to scarring.
- Difficulty swallowing (dysphagia) burp burning under the ribs or chest lesions of the esophagus and the stomach and esophageal reflux. (Gastroesophageal reflux) due to fibrosis in the gastrointestinal tract.
- Red fullness, bloating, distension
